Going outside United States for vacation while on H1B

[tyro]

Hello Guys,
I used to have H1B with company X. I went to my country, got H1B stamped on my passport for Company X and came back to US. After few months I change my job and now I have new H1B with Company Y. So in this case, if i want to go on vacation outside US, will there be any problem going out or getting back ? I would be very grateful if someone can point me to right official website or link.

Thanks
Tyro