Advice on applying for US visit visa from Pakistan

[Hussain Merchant]

hello, my name is hussain merchant, age 43, never married, I'm from lahore, pakistan, me and my mother moved from karachi to lahore in january and staying with my sister. I'm going to apply for US visit visa in late june or early july 2017, ALONE. I have applied for US visa once in 1994 and then january 2000, got rejected both times. they said i will stay there and won't come back.
I was a technical support engineer in an IT company in karachi, in lahore, im still looking for a job but at the time being i have started an online business (just selling some brand replicas on ********).
I am just curious, because I am living in a Muslim country that's why i am little skeptical to apply due to this donald trump administration.
My income is not much but i can arrange PKR 450,000 (over $4000) to show in bank statement.
i have visited Bangkok and kuala lumpur in 2005 and dubai in 2008. just for couple of weeks.
i will be visiting my uncle in Austin, Texas, he lives with his family there for over 20 years, he owns a store. he will send me an invitation letter.
so please guide should i apply or will i be rejected again because i have to pay $160-$180 visa fees and have to travel to another city where embassy is located.
also please guide me how should i prepare this time around.
thank you

[inadmissible]

On paper, you are not a good candidate for a tourist visa, because you have weak ties to your home abroad