Can a minor travel on a B2 visa without parents?

[meill]

My wife is a U.S. born citizen and we’d like for her younger brother, a Mexican citizen who is 11, to come to the U.S. to visit us in Florida.

Could he get a visa approved without his parents if my wife accompanies him over the border via ground/air travel? Im having a hard time getting an answer. Thank you in advance! https://19216811.cam/